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Complementary and alternative medicine for the treatment of diabetes and associated complications: A review on therapeutic role of polyphenols - ScienceDirect

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The latter in response to stimulation by intestinal microbial antigens, particularly LPS, upregulate the production of proinflammatory cytokines (e.g., IL-1β, IL-6, TNF) and reactive oxygen species (ROS), contributing to the enhancement of pro-inflammatory reactions (Van Spaendonk et al., 2017)