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3.2 Role of TGF-β in radiation skin fibrosis TGF-β is a cytokine intricately involved in the fibrotic process across various organs and tissues ( 3.2.1 TGF-β Signaling and cellular mechanisms in radiation-induced fibrosis TGF-β exerts its effects through the activation and proliferation of fibroblasts, leading to ECM accumulation ( TGF-β expression is dose-dependent on radiation exposure, binding to its receptors to form a trimeric complex which can lead to tissue fibrosis ( Figure 2 )