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In CD4 + T cells, sirtuin-2 deacetylates c-Jun and histones at the IL2 gene, decreasing IL-2 production [239] (Figure 3)

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This mirrors findings in mammals where Hs PP5 dephosphorylates various kinases, such as SAPKs and apoptosis signal-regulating kinase 1 (ASK1), which are involved in apoptosis and stress responses 40

While results vary depending on lifestyle and training intensity